Understanding how meprin proteins contribute to tissue injury
Official title: Mechanistic Studies on Meprin Metalloproteases and Meprin-Substrate Interactions in Tissue Injury
Funded at North Carolina Agri & Tech St Univ · NIH-11092182 · Data updated 2026-11-12
This study is looking at how certain proteins called meprin metalloproteases might affect tissue damage in diseases like Alzheimer's and kidney disease, with the hope of finding new ways to help treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina Agri & Tech St Univ NIH-funded |
| Lab location | 1 site (Greensboro, United States) |
| Project start | June 1, 2021 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $360,000 |
| NIH project number | 5R35GM141537-05 |
| Project ID | NIH-11092182 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from inflammatory diseases, neurodegenerative disorders, or kidney-related conditions.
✕Less likely to help
Patients with non-inflammatory conditions or those not affected by tissue injury may not benefit from this research.
What this research studies
This research investigates the role of meprin metalloproteases in tissue injury, particularly in conditions like Alzheimer's disease and kidney disease. By examining how these proteins interact with various substrates, the study aims to uncover the cellular and molecular mechanisms that drive inflammation and fibrosis. The research employs advanced molecular biology techniques and animal models to explore the effects of meprin activity on disease progression, which could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases associated with tissue injury, such as Alzheimer's and kidney disease.
How similar studies have gone: Previous research has shown that targeting similar pathways in tissue injury has led to promising therapeutic advancements, indicating potential for success in this area.
Where this research is happening
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North Carolina Agri & Tech St Univ
Greensboro, United States Active
Researchers
- Principal investigator: Ongeri, Elimelda Moige — North Carolina Agri & Tech St Univ
- Study coordinator: Ongeri, Elimelda Moige
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.