Understanding how memory T cells work in the mouth
Official title: Regulation and Function of Oral Resident Memory T Cells
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10903853 · Data updated 2026-11-12
This study is looking at special immune cells in your mouth that help protect against infections and may play a role in allergies and autoimmune diseases, with the goal of finding new ways to improve treatments for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00DE031014-04 |
| Project ID | NIH-10903853 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of oral infections, autoimmune diseases, or those interested in immunological health.
✕Less likely to help
Patients with no history of oral health issues or those not affected by autoimmune diseases may not benefit from this research.
What this research studies
This research investigates the role of tissue resident memory T cells (TRM) in the oral cavity, which are crucial for protecting against infections and may influence allergic and autoimmune diseases. By focusing on how these cells function and develop in the mouth, the study aims to uncover their potential for improving treatments for various immunological disorders. The research employs advanced methodologies to analyze the behavior and characteristics of TRM in oral tissues, providing insights that could lead to novel therapeutic strategies. Patients may benefit from a better understanding of how to enhance immune responses in the mouth, particularly in relation to infections and autoimmune conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for oral infections and autoimmune diseases by harnessing the power of memory T cells.
How similar studies have gone: While there has been extensive research on memory T cells in other mucosal sites, this specific focus on oral TRM is relatively novel and untested.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Stolley, James Michael — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Stolley, James Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.