Understanding how memory T cells develop and persist in the body
Regulation of memory T cell differentiation and long-term maintenance
['FUNDING_P01'] · UNIVERSITY OF FLORIDA · NIH-10885046
This study is looking at how certain immune cells called T cells become memory cells that help protect us from infections and cancer, and it aims to find out which types of these memory T cells work best, which could lead to better vaccines and cancer treatments.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10885046 on ClinicalTrials.gov |
What this research studies
This research investigates the processes that guide T cells, a type of immune cell, to differentiate into memory cells that can provide long-term protection against infections and cancers. By examining the transcriptional and chromatin regulatory factors involved in this differentiation, the study aims to identify which memory T cell subsets are most effective in fighting malignancies and infections. The research employs advanced techniques to analyze the functional diversity of these T cells and their genetic programming, which could enhance vaccine development and cancer immunotherapy strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of infections or cancers who may benefit from enhanced immune responses.
Not a fit: Patients with autoimmune disorders or those who do not have a history of infections or cancers may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and cancer treatments by enhancing the effectiveness of memory T cells.
How similar studies have performed: Other research has shown promising results in understanding T cell differentiation and its implications for immunotherapy, indicating that this approach has potential for success.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOLDRATH, ANANDA W — UNIVERSITY OF FLORIDA
- Study coordinator: GOLDRATH, ANANDA W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.