Understanding how memory B cells respond to influenza vaccination and infection
Identification and characterization of effector memory B cell populations that dominate memory responses to subsequent influenza infection and vaccination
['FUNDING_R01'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-10894589
This study is looking at how special immune cells called memory B cells help your body fight off the flu after you get infected or vaccinated, with the goal of finding ways to make flu vaccines even better for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-10894589 on ClinicalTrials.gov |
What this research studies
This research investigates the role of memory B cells in the immune response to influenza infections and vaccinations. By isolating and characterizing these cells, the study aims to uncover how they contribute to the production of antibodies that protect against the flu. The approach involves analyzing blood samples to better understand the dynamics of these immune cells and their effectiveness in generating a robust response to the virus. This knowledge could lead to improved vaccine strategies that enhance protection against seasonal and pandemic influenza.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who receive annual influenza vaccinations and may be at risk for severe flu infections.
Not a fit: Patients who are not eligible for influenza vaccination or those with compromised immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective influenza vaccines that provide better protection against the virus.
How similar studies have performed: Previous research has shown promise in understanding B cell responses to vaccines, indicating that this approach could yield valuable insights.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUND, FRANCES E. — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: LUND, FRANCES E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.