Understanding how memory B cells develop and respond to infections
Official title: Differentiation of memory B cells requires EZH2 and epigenetic remodeling
Funded at Emory University · NIH-10974015 · Data updated 2026-11-12
This study is looking at how certain changes in our immune cells, called memory B cells, help our bodies remember and fight off infections better, using mice to learn more about how these cells develop and work.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | June 23, 2023 |
| Project end | June 22, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AI172377-02 |
| Project ID | NIH-10974015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that affect the immune system or those interested in how their immune responses to infections may be improved.
✕Less likely to help
Patients with stable immune conditions who are not currently facing infections may not receive direct benefits from this research.
What this research studies
This research investigates the differentiation of memory B cells, which are crucial for long-lasting immunity against infections. By using mouse models, the study aims to explore how epigenetic changes, specifically histone modifications, influence the development and function of these immune cells. The researchers will analyze the differences between memory B cells that arise from germinal centers and those that do not, providing insights into how the immune system adapts to various pathogens. This work could lead to a better understanding of immune responses and potential therapies for infections.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses, potentially leading to improved vaccines and therapies for infectious diseases.
How similar studies have gone: Previous research has shown success in understanding immune cell differentiation through epigenetic mechanisms, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Wiggins, Keenan — Emory University
- Study coordinator: Wiggins, Keenan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.