Understanding how memories are formed and affected by aging in the brain.
Official title: Assessing the Dynamics of Hippocampal Neuronal Engrams in Memory Formation and Aging
Funded at Boston University Medical Campus · NIH-10928799 · Data updated 2026-11-12
This study is looking at how the hippocampus, a part of the brain important for memory, works as we age and how conditions like Alzheimer's affect it, with the hope of finding ways to improve memory for those experiencing decline.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,694 |
| NIH project number | 5F99NS135814-02 |
| Project ID | NIH-10928799 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing memory issues or those diagnosed with early-stage Alzheimer's disease.
✕Less likely to help
Patients with severe cognitive impairment or those in advanced stages of Alzheimer's may not benefit from this research.
What this research studies
This research investigates the role of the hippocampus in memory formation and retrieval, particularly how it is impacted by aging and neurodegenerative diseases like Alzheimer's. By examining the connections between neurons in the hippocampus, the study aims to identify the mechanisms that underlie memory storage and recall. The researchers will utilize advanced techniques to isolate and analyze specific neuron populations that are activated during learning and memory processes. This approach could lead to insights into how memory decline occurs with age and how it might be treated.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating memory decline associated with aging and Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding memory mechanisms through similar approaches, indicating potential for success in this area.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Monasterio, Amy — Boston University Medical Campus
- Study coordinator: Monasterio, Amy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.