Understanding how membrane proteins fold and assemble in cells
Membrane Protein Folding and Assembly
This study is looking at how certain proteins in our cells are made and put together, which is really important for keeping us healthy, and it could help us understand diseases like cystic fibrosis that happen when these proteins don't fold correctly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11191400 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the folding and assembly of membrane proteins, which are crucial for proper cellular function. By using a model system involving E. coli, the researchers aim to explore how these proteins are targeted, secreted, and inserted into membranes. The study focuses on the role of the SecA motor ATPase, a key player in this process, and employs engineered chimeric proteins to assess stability and functionality. This work could provide insights into diseases like cystic fibrosis that arise from protein misfolding.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to membrane protein misfolding, such as cystic fibrosis.
Not a fit: Patients with conditions unrelated to membrane protein function or misfolding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases caused by membrane protein misfolding, improving patient outcomes.
How similar studies have performed: Previous research has shown success in understanding membrane protein dynamics, but this specific approach using E. coli as a model is relatively novel.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: White, Stephen H. — University of California-Irvine
- Study coordinator: White, Stephen H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.