Understanding how membrane proteins fold and are broken down in cells
Folding and degradation of membrane proteins
['FUNDING_OTHER'] · MICHIGAN STATE UNIVERSITY · NIH-11030289
This study looks at how certain helpers in our cells make sure proteins are shaped correctly and get rid of any that are not, which is important for keeping our cells healthy, and it uses simple bacteria to learn more about these processes that could also apply to more complex cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MICHIGAN STATE UNIVERSITY (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-11030289 on ClinicalTrials.gov |
What this research studies
This research investigates the processes that govern the folding and degradation of membrane proteins, which are crucial for maintaining healthy cell function. By examining how molecular chaperones assist in protein folding and how proteases degrade misfolded proteins, the study aims to fill gaps in our understanding of protein quality control. The research utilizes models from E. coli to explore these mechanisms in a controlled environment, providing insights that could apply to both prokaryotic and eukaryotic cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to protein misfolding disorders, such as certain neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein folding or degradation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating diseases related to protein misfolding and degradation.
How similar studies have performed: Previous research has shown success in understanding protein folding and degradation mechanisms, but this specific focus on membrane proteins is relatively novel.
Where this research is happening
EAST LANSING, UNITED STATES
- MICHIGAN STATE UNIVERSITY — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HONG, HEEDEOK — MICHIGAN STATE UNIVERSITY
- Study coordinator: HONG, HEEDEOK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.