Understanding how melanocyte cells develop and function
Study of melanocyte lineage through SASH1 and associated proteins
This study is looking at the skin cells that give us our color and how they work, especially focusing on a specific gene, to find new ways to help people with skin conditions or melanoma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10816607 on NIH RePORTER |
What this research studies
This research investigates the biology of melanocytes, the cells responsible for skin pigmentation, and their stem cells. It aims to uncover the molecular mechanisms that regulate these cells, particularly focusing on a gene called SASH1 and its associated proteins. By studying how these cells proliferate, differentiate, and maintain themselves, the research seeks to identify new therapeutic targets for pigmentation disorders and melanoma. Patients may benefit from insights that could lead to innovative treatments for skin-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with pigmentation disorders or those at risk for melanoma.
Not a fit: Patients with conditions unrelated to melanocyte function or those not affected by pigmentation disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for pigmentation disorders and melanoma, improving patient outcomes.
How similar studies have performed: Other research has shown promise in understanding melanocyte biology, but the specific focus on SASH1 is relatively novel.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Shellman, Yiqun G — University of Colorado Denver
- Study coordinator: Shellman, Yiqun G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.