Understanding how meiosis works and its role in fertility and birth defects
Official title: Molecular Mechanism and Regulation of Meiosis
Funded at University of Pennsylvania · NIH-11054639 · Data updated 2026-11-12
This study is looking at how cells make sperm and eggs and what can go wrong in that process, which might help us understand why some people have trouble getting pregnant or why some babies are born with issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | March 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $522,712 |
| NIH project number | 5R35GM153384-02 |
| Project ID | NIH-11054639 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing infertility or those with a family history of birth defects.
✕Less likely to help
Patients who are not experiencing fertility issues or do not have a history of chromosomal abnormalities may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that regulate meiosis, the process by which cells divide to form gametes (sperm and eggs). It aims to identify key factors involved in meiosis and how defects in this process can lead to infertility and birth defects. By using genomic and proteomic techniques, the study will explore the interactions between various proteins that are crucial for proper chromosome pairing and segregation during meiosis. This research could provide insights into the underlying causes of reproductive issues and congenital abnormalities.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility and genetic birth defects.
How similar studies have gone: Previous research has shown success in understanding meiotic processes and their implications for fertility, indicating that this approach has a solid foundation.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Wang, Peijing Jeremy — University of Pennsylvania
- Study coordinator: Wang, Peijing Jeremy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.