Understanding How Medicines Move Inside the Body
Predicting Intracellular Drug Concentrations In The Presence Of Transporters
['FUNDING_R01'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-11163429
This work aims to better predict how much medicine reaches different parts of your body and how long it stays there, which can help create better treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11163429 on ClinicalTrials.gov |
What this research studies
This project develops advanced computer models to understand how medicines travel through the body, including how they cross cell membranes, are affected by blood flow, and are processed by the body. We are building new ways to predict drug levels inside and outside cells, taking into account how the body's natural transporters move drugs around. This helps us understand how drugs are absorbed, distributed, and cleared, which is crucial for developing effective and safe medications. The goal is to provide better tools for predicting how drugs will work in people.
Who could benefit from this research
Good fit: This foundational modeling work does not directly involve patient participation, but its insights could benefit any patient taking medication by improving drug design.
Not a fit: Patients not currently taking medications or those whose conditions are not treated by pharmaceutical drugs may not directly benefit from this specific modeling research.
Why it matters
Potential benefit: If successful, this work could lead to more efficient and cost-effective drug development, ultimately resulting in safer and more effective medications for patients.
How similar studies have performed: While the specific modeling framework (PermQ) is novel, the underlying principles of pharmacokinetic modeling have been successfully applied in drug development for many years.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KORZEKWA, KENNETH RAY — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: KORZEKWA, KENNETH RAY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.