Understanding How Medicines Interact with Proteins
Identification and quantification of drug-protein adducts by mass spectrometry
This project is developing new ways to find out why some medicines cause unexpected side effects in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11131259 on NIH RePORTER |
What this research studies
Sometimes, medicines can cause unwanted side effects that are hard to predict or understand. This often happens when a drug's breakdown products attach to proteins in the body, forming what are called 'adducts.' Our goal is to create better tools to identify and measure these drug-protein attachments, especially those linked to adverse reactions. By doing so, we hope to better understand why certain drugs cause problems and make new medications safer for everyone. We are focusing on drugs already known to cause adverse events in patients.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to benefit all patients by improving drug safety.
Not a fit: Patients not taking medications or not experiencing adverse drug reactions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to safer medications and a better understanding of why some drugs cause adverse reactions, ultimately protecting patients.
How similar studies have performed: While previous efforts have struggled to comprehensively identify drug-protein interactions, this project introduces innovative proteomic methods to address this challenge.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Isoherranen, Nina — University of Washington
- Study coordinator: Isoherranen, Nina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.