Understanding how mechanical stretch affects lung fibrosis progression
Modeling pulmonary fibrosis progression caused by differential mechanical stretch
This study is looking at how lung tissue stretching affects the worsening of idiopathic pulmonary fibrosis (IPF), with the goal of finding better ways to understand and treat this lung disease for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10895369 on NIH RePORTER |
What this research studies
This research investigates idiopathic pulmonary fibrosis (IPF), a serious lung disease that progresses from the outer parts of the lungs to the center. The study aims to uncover the mechanisms behind this progression by examining how different levels of mechanical stretch in lung tissue influence fibrosis development. Researchers will create a specialized engineered lung slice model to simulate the natural lung environment and study how mechanical forces contribute to the disease's advancement. This approach seeks to provide insights that could lead to better understanding and treatment options for patients with IPF.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with idiopathic pulmonary fibrosis or those at risk of developing the condition.
Not a fit: Patients with other types of lung diseases or those without any lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or halt the progression of pulmonary fibrosis in patients.
How similar studies have performed: While the specific approach of using engineered lung slices to study mechanical stretch in fibrosis is novel, related research has shown promise in understanding lung diseases through biomechanical modeling.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Zhao, Ruogang — State University of New York at Buffalo
- Study coordinator: Zhao, Ruogang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.