Understanding how mechanical stresses affect tissue healing after mesh implantation
Official title: Mesh complications: The role of local mechanical stresses on tissue remodeling following mesh implantation
Funded at Magee-Women's Res Inst and Foundation · NIH-10894135 · Data updated 2026-11-12
This study is looking at how different types of mesh used in surgeries for pelvic organ prolapse can affect healing and complications, with the goal of finding the best options to help women recover more comfortably and successfully.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magee-Women's Res Inst and Foundation NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project start | August 15, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $591,883 |
| NIH project number | 5R01HD083383-09 |
| Project ID | NIH-10894135 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who are considering or have undergone surgery for pelvic organ prolapse.
✕Less likely to help
Patients who have not undergone pelvic organ prolapse surgery or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates the complications associated with pelvic organ prolapse (POP) surgeries that use mesh implants. It focuses on how different mesh designs and their mechanical properties influence tissue remodeling and healing. By utilizing advanced computational models and ex vivo tests, the study aims to identify the optimal mesh configurations that minimize complications such as pain and mesh exposure. The findings could lead to improved surgical outcomes for women undergoing POP repair.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective surgical options for women with pelvic organ prolapse.
How similar studies have gone: Previous research has shown promising results with similar approaches in optimizing mesh designs to reduce complications.
Where this research is happening
-
Magee-Women's Res Inst and Foundation
Pittsburgh, United States Active
Researchers
- Principal investigator: Moalli, Pamela a. — Magee-Women's Res Inst and Foundation
- Study coordinator: Moalli, Pamela a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.