Understanding how mechanical stress affects lung tumor growth
Official title: Mechanical Stress and Lung Tumor Progression
Funded at University of Utah · NIH-11078277 · Data updated 2026-11-12
This study is looking at how the pressure from breathing affects the growth of early lung tumors and could help find new ways to treat lung cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $461,181 |
| NIH project number | 5R01CA290182-02 |
| Project ID | NIH-11078277 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with early-stage lung tumors or those at high risk for developing lung adenocarcinoma.
✕Less likely to help
Patients with advanced lung cancer or those without any lung tumors may not benefit from this research.
What this research studies
This research investigates the role of mechanical stress in the progression of early lung tumors to lung adenocarcinoma. By examining how strain from breathing influences tumor growth and the surrounding tissue, the study aims to uncover the biochemical and mechanical interactions that drive cancer development. The researchers will use advanced imaging techniques and computational models to analyze tumor behavior and the impact of the extracellular matrix on tumor progression. Patients may benefit from insights that could lead to new treatment strategies targeting these mechanical factors.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that prevent the progression of early lung tumors, potentially improving survival rates.
How similar studies have gone: Previous research has shown promising results in understanding the mechanical aspects of tumor progression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Weiss, Jeffrey a. — University of Utah
- Study coordinator: Weiss, Jeffrey a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.