Understanding how mechanical signals promote muscle growth
Official title: Identifying the Structural Adaptations that Drive the Mechanically Induced Growth of Skeletal Muscle
Funded at University of Wisconsin-Madison · NIH-10893546 · Data updated 2026-11-12
This study is looking at how physical signals help your muscles grow bigger and stronger, which is important for staying healthy, especially for people dealing with muscle-wasting issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 25, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $516,040 |
| NIH project number | 5R01AR082816-02 |
| Project ID | NIH-10893546 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing muscle atrophy due to aging, bed rest, or chronic diseases.
✕Less likely to help
Patients with stable muscle mass and no risk factors for muscle loss may not benefit from this research.
What this research studies
This research investigates how mechanical signals influence the growth of skeletal muscle, which is crucial for maintaining muscle mass and overall health. The study aims to uncover the mechanisms behind muscle hypertrophy, focusing on how existing muscle fibers increase in size rather than the formation of new fibers. By examining the balance between protein synthesis and degradation, the research seeks to identify the structural changes that occur in muscle fibers during growth. This could lead to insights on how to enhance muscle health, especially in individuals facing muscle-wasting conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing muscle loss and improving muscle health in various populations.
How similar studies have gone: Previous research has shown promising results in understanding muscle growth mechanisms, but this specific approach to identifying structural adaptations is relatively novel.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Hornberger, Troy a — University of Wisconsin-Madison
- Study coordinator: Hornberger, Troy a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.