Understanding how mechanical properties of tissues affect cancer spread
Official title: A Mechanoimmunological Basis for Metastatic Site Preference
Funded at Sloan-Kettering Inst Can Research · NIH-10998481 · Data updated 2026-11-12
This study looks at how the stiffness of different tissues in the body affects where cancer cells move and spread, with the hope of finding new ways to treat metastatic cancer that could help patients like you.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 6, 2024 |
| Project end | July 5, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31CA294974-01 |
| Project ID | NIH-10998481 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with metastatic cancer, particularly those with bone metastases.
✕Less likely to help
Patients with localized cancer that has not spread or those with non-cancerous conditions may not benefit from this research.
What this research studies
This research investigates how the mechanical properties of different tissues influence where cancer cells spread in the body. By examining the stiffness of various environments, the study aims to understand how cancer cells interact with immune cells, particularly during the process of metastasis. The research employs advanced techniques like atomic force microscopy and single-cell RNA sequencing to analyze these interactions in detail. Patients may benefit from insights that could lead to new therapeutic strategies targeting metastatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce the spread of cancer to specific organs.
How similar studies have gone: Other research has shown promising results in understanding the mechanical properties of tissues and their influence on cancer progression, indicating that this approach has potential for success.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Elbanna, Yassmin — Sloan-Kettering Inst Can Research
- Study coordinator: Elbanna, Yassmin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.