Understanding how mechanical forces influence cell development in embryos
Investigating the role of nuclear mechanics in the regulation of chromatin structure and embryonic cell fate
['FUNDING_CAREER'] · YALE UNIVERSITY · NIH-10903910
This study looks at how physical forces in the early stages of pregnancy can influence the development of important cell types, which could help us understand more about successful pregnancies and find new ways to treat infertility.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10903910 on ClinicalTrials.gov |
What this research studies
This research investigates how mechanical forces affect the differentiation of two critical cell types during early embryonic development: the inner cell mass (ICM) and the trophectoderm (TE). By examining the role of the Hippo signaling pathway and chromatin structure, the study aims to uncover how these mechanical influences can regulate gene expression and cell fate. Patients may benefit from insights gained into the mechanisms of successful pregnancy and potential treatments for infertility. The research employs advanced techniques to analyze cellular responses to mechanical stimuli in a controlled laboratory setting.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals experiencing infertility or complications related to early pregnancy.
Not a fit: Patients who are not seeking to conceive or who are not experiencing pregnancy-related issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatments for infertility and complications during early pregnancy.
How similar studies have performed: Other research has shown promising results in understanding the role of mechanical forces in cell differentiation, making this approach both relevant and potentially impactful.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHERRARD, ALICE LOUISA — YALE UNIVERSITY
- Study coordinator: SHERRARD, ALICE LOUISA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.