Understanding how mechanical forces affect heart development
Mechanobiology of Cardiac Outflow Tract Morphogenesis
This study is looking at how the heart develops after birth and how things like pressure and tension can affect its growth, especially in babies with heart defects, to help find better ways to prevent or treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11023090 on NIH RePORTER |
What this research studies
This research investigates the growth and development of the cardiac outflow tract, which is crucial for proper heart function after birth. It focuses on how mechanical forces, such as pressure and tension, influence the formation of heart structures, particularly in cases of congenital heart defects. By using advanced technology to measure these forces and their effects on gene and protein expression, the research aims to uncover the underlying mechanisms that lead to heart defects. This could provide insights into how to prevent or treat these conditions in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns and fetuses diagnosed with congenital heart defects.
Not a fit: Patients with fully developed hearts and no history of congenital heart defects may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for congenital heart defects.
How similar studies have performed: While the study of mechanical forces in heart development is a relatively novel approach, previous research has shown promising results in understanding other aspects of cardiac biology.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Butcher, Jonathan Talbot — Cornell University
- Study coordinator: Butcher, Jonathan Talbot
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.