Understanding how mechanical forces affect growth and shape in cells
Regulation of Growth and Morphogenesis
This study is looking at how cells sense and react to physical forces, which helps them grow and shape properly, and it's especially important for understanding issues like cancer and birth defects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project ID | NIH-11062534 on NIH RePORTER |
What this research studies
This research explores the molecular mechanisms that regulate how cells perceive and respond to mechanical forces, integrating biochemical and biomechanical signals to influence growth and shape during various biological processes. The team is particularly focused on how tension at cell junctions affects signaling pathways that control tissue growth, especially in the context of development and disease. By studying these processes in model organisms, the research aims to uncover insights that could lead to advancements in treating conditions like cancer and birth defects.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions related to abnormal tissue growth or development, such as certain cancers or congenital birth defects.
Not a fit: Patients with conditions unrelated to cellular growth regulation or those not experiencing developmental issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to abnormal cell growth and shape, such as cancers and developmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of mechanical forces in cell behavior, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Piscataway, United States
- Rutgers, the State Univ of N.j. — Piscataway, United States (Active)
Researchers
- Principal investigator: Irvine, Kenneth D — Rutgers, the State Univ of N.j.
- Study coordinator: Irvine, Kenneth D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.