Understanding how mechanical forces affect breast cancer progression through EPHA2 signaling
EPHA2 Receptor Signaling in Breast Cancer Mechanotransduction
This study is looking at how a specific protein called EPHA2 in breast cancer cells reacts to the stiffness of the tissue around them, which could help us understand how these cells spread and find new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11087476 on NIH RePORTER |
What this research studies
This research investigates the role of the EPHA2 receptor in breast cancer, particularly how it responds to mechanical forces from the surrounding tissue. By using advanced cell culture techniques and animal models, the researchers aim to uncover how changes in the stiffness of the extracellular matrix influence cancer cell behavior, including their ability to invade and metastasize. The study will explore both the promoting and inhibiting effects of EPHA2 signaling on cancer progression, providing insights into potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer, particularly those whose tumors exhibit aggressive characteristics.
Not a fit: Patients with non-breast cancer conditions or those whose tumors do not involve EPHA2 signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that inhibit breast cancer invasion and metastasis by targeting EPHA2 signaling pathways.
How similar studies have performed: Previous research has shown promising results in targeting similar signaling pathways in cancer treatment, suggesting that this approach may also yield beneficial outcomes.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Pasquale, Elena B — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Pasquale, Elena B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.