Understanding how mechanical forces affect asthma in the airway epithelium
Mechanogenomics of the asthmatic airway epithelium
This study is looking at how physical forces in the airways of asthma patients can change their structure and function, and it aims to find out more about these changes to help create better treatments, with the help of patients who can provide samples and information.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10891505 on NIH RePORTER |
What this research studies
This research investigates the role of mechanical forces in the airway epithelium of asthma patients, focusing on how these forces can lead to changes in the airway structure and function. By combining advanced genomic techniques and clinical data, the study aims to uncover the mechanisms behind airway remodeling that occurs in asthma, which may not be solely driven by inflammation. Patients may be involved in providing samples and data that will help researchers understand these processes better and develop new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with asthma, particularly those experiencing chronic symptoms despite standard treatments.
Not a fit: Patients with asthma who have not responded to any treatments or those with other underlying respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that target the mechanical aspects of asthma, potentially improving management and outcomes for patients.
How similar studies have performed: Other research has shown promising results in understanding the mechanical aspects of asthma, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: De Marzio, Margherita — Brigham and Women's Hospital
- Study coordinator: De Marzio, Margherita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.