Understanding how mechanical changes affect aortic aneurysms
Mechano-epigenetic disruption in aortic aneurysm
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11000333
This study is looking at how certain cells in the aorta respond to changes in pressure and how problems with this sensing might lead to thoracic aortic aneurysms, with the hope of finding new ways to treat or prevent this serious condition for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11000333 on ClinicalTrials.gov |
What this research studies
This research investigates the role of smooth muscle cell mechanosensing in the development of thoracic aortic aneurysms (TAA). It aims to understand how disruptions in the ability of these cells to sense mechanical changes in the aorta contribute to the disease. By exploring the molecular and epigenetic pathways involved, the study seeks to identify potential new therapeutic targets for TAA. Patients may benefit from insights that could lead to improved treatments or preventive strategies for this serious condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with thoracic aortic aneurysms or those at high risk for developing this condition.
Not a fit: Patients with aortic aneurysms caused by non-mechanical factors or those who do not have a thoracic aortic aneurysm may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent the progression of aortic aneurysms and reduce the risk of life-threatening complications.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of aortic aneurysms, but this specific approach focusing on mechanosensing is relatively novel.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOMEZ, DELPHINE — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: GOMEZ, DELPHINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.