Understanding how measles virus spreads in airway cells
Official title: A membrane fusion apparatus trailblazes measles virus spread in airway cells
Funded at University of Iowa · NIH-11231900 · Data updated 2026-11-12
This study is looking at how the measles virus spreads between cells in the lungs, using special lab-grown lung cells, to help us understand why measles is so contagious compared to other viruses.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | June 17, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $427,625 |
| NIH project number | 1R21AI187987-01A1 |
| Project ID | NIH-11231900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of measles infection or those involved in public health efforts against measles outbreaks.
✕Less likely to help
Patients who have already been vaccinated against measles or those with no exposure risk may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the measles virus spreads from cell to cell in airway epithelial cells. Using a unique cell culture model derived from human donor lungs, the study aims to uncover how the virus forms infectious centers that facilitate its transmission. The researchers will explore the role of specific viral proteins in creating intercellular pores that allow the virus to move between cells. By understanding these processes, the research hopes to shed light on the contagious nature of the measles virus compared to other respiratory viruses.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing measles outbreaks and enhancing vaccine efficacy.
How similar studies have gone: Other research has shown success in understanding viral transmission mechanisms, but this specific approach to studying measles virus spread is relatively novel.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Singh, Brajesh Kumar — University of Iowa
- Study coordinator: Singh, Brajesh Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.