Understanding how MDMA affects social behavior in the brain
Official title: Mapping Neural Circuit Activity Mediating MDMA's Prosocial Effect
Funded at Stanford University · NIH-11005741 · Data updated 2026-11-12
This study is looking at how MDMA might help people with PTSD feel more connected and empathetic, using mice to understand how it affects the brain, with the goal of finding safer treatments that can boost social feelings without the risks of MDMA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | March 2, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $470,811 |
| NIH project number | 5R01MH130591-03 |
| Project ID | NIH-11005741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from PTSD or related conditions who may benefit from enhanced social connectivity and emotional support.
✕Less likely to help
Patients who do not have PTSD or related psychiatric conditions may not receive any benefit from this research.
What this research studies
This research investigates the effects of MDMA, a substance known for its potential to enhance feelings of social connection and empathy, particularly in the context of treating PTSD. Using mouse models, the study aims to map brain activity associated with MDMA-induced behaviors, which could lead to the development of new therapeutic strategies that enhance sociability without the risks of MDMA itself. By combining behavioral tests with advanced imaging techniques, the research seeks to identify novel treatments that mimic the positive effects of MDMA while minimizing its abuse potential.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve social functioning and emotional well-being for individuals with PTSD and other psychiatric conditions.
How similar studies have gone: Previous research has shown promising results in using MDMA for therapeutic purposes, particularly in PTSD treatment, indicating that this approach may build on established findings.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Heifets, Boris Dov — Stanford University
- Study coordinator: Heifets, Boris Dov
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.