Understanding how maternal immune factors affect fetal blood cell production to improve newborn health
Official title: Determining themechanism of maternal IL-10 restriction of fetal emergency myelopoiesis to improve neonataloutcomes
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10996651 · Data updated 2026-11-12
This study is looking at how infections in pregnant moms can affect their baby's immune system and health, focusing on a protein called IL-10 that might limit important immune cells; the goal is to find ways to help improve the baby's immune response and overall health after birth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $414,026 |
| NIH project number | 1R01HD116402-01 |
| Project ID | NIH-10996651 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals experiencing infections or inflammation that may affect their fetus's immune development.
✕Less likely to help
Patients who are not pregnant or those whose pregnancies are not affected by infections or inflammatory conditions may not benefit from this research.
What this research studies
This research investigates how maternal infections during pregnancy can negatively impact the immune system of the fetus, leading to serious health issues for newborns. The study focuses on the role of a specific immune protein, interleukin-10 (IL-10), which may limit the production of essential immune cells called neutrophils in the fetus. By exploring the mechanisms behind this restriction, the research aims to uncover how maternal inflammation and serotonin levels in the placenta affect fetal blood cell development. The ultimate goal is to identify ways to enhance neonatal outcomes by improving fetal immune responses.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing infections and enhancing the health of newborns exposed to maternal infections during pregnancy.
How similar studies have gone: While the specific mechanisms being investigated are novel, previous research has shown that maternal health significantly impacts neonatal outcomes, suggesting potential for success in this area.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Collins, Amelie — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Collins, Amelie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.