Understanding how maternal immune activation affects brain development and mental health
Targeted inhibition of stress associated pathways to promote resilience against maternal immune activation
['FUNDING_R15'] · MCPHS UNIVERSITY · NIH-10358119
This study looks at how a mother's illness during pregnancy, like having the flu, might affect her child's brain development and lead to challenges in social skills and thinking later on, and it aims to find ways to help protect kids from these risks.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MCPHS UNIVERSITY (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10358119 on ClinicalTrials.gov |
What this research studies
This research investigates how maternal immune activation during pregnancy, such as when a mother experiences an illness like the flu, can increase the risk of neurodevelopmental disorders in children. By using animal models, the study aims to explore the changes in brain development caused by this immune response and how these changes may lead to social and cognitive impairments later in life. The researchers are particularly focused on the role of stress-related genes and environmental factors that could help protect against these negative outcomes. The ultimate goal is to identify potential interventions that could promote resilience in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to maternal immune activation during pregnancy and may be at risk for neurodevelopmental disorders.
Not a fit: Patients who have not been exposed to maternal immune activation or do not have neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating neurodevelopmental disorders linked to maternal immune activation.
How similar studies have performed: Other research has shown promising results in understanding the effects of maternal immune activation on brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- MCPHS UNIVERSITY — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KENTNER, AMANDA — MCPHS UNIVERSITY
- Study coordinator: KENTNER, AMANDA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.