Understanding how maternal genes affect early embryo development
Identification of regulators in the vertebrate egg-to-embryo transition
['FUNDING_CAREER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10663791
This study looks at how a mother's genes help shape the early development of her baby before the baby's own genes kick in, using special imaging tools to see how these genes work, which could help us understand why some pregnancies end in miscarriage.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10663791 on ClinicalTrials.gov |
What this research studies
This research investigates the critical role of maternal genes in the early stages of embryo development across vertebrates. It focuses on how these genes influence the transition from egg to embryo, particularly before the embryo's own genes are activated. By using advanced imaging techniques, the study aims to observe the behavior of specific maternal gene products and their impact on embryo formation. The findings could provide insights into the causes of miscarriages and early pregnancy loss linked to maternal gene defects.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have experienced recurrent miscarriages or have a family history of congenital abnormalities.
Not a fit: Patients who are not planning to conceive or those without a history of pregnancy loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for preventing miscarriages and congenital defects.
How similar studies have performed: Previous research has shown promising results in understanding maternal gene functions, but this specific approach is relatively novel.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORAVEC, CARA — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: MORAVEC, CARA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.