Understanding how maternal dengue antibodies affect Zika virus risk during pregnancy
Enhanced susceptibility to Zika virus during pregnancy: a role for maternal dengue antibodies
This study is looking at how antibodies from dengue virus in pregnant women might affect their risk of getting sick from the Zika virus, with the goal of understanding how this could impact the health of their babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10886563 on NIH RePORTER |
What this research studies
This research investigates the relationship between maternal dengue virus antibodies and the susceptibility to Zika virus infection during pregnancy. It aims to understand how preexisting immunity to dengue may influence the severity of Zika virus disease, particularly in pregnant women. The study will analyze biological samples and data from affected populations to explore the mechanisms of antibody-dependent enhancement, which may lead to increased risks of birth defects. By identifying these factors, the research seeks to provide insights that could inform public health strategies and clinical practices.
Who could benefit from this research
Good fit: Ideal candidates for participation include pregnant women who have a history of dengue virus infection or live in areas where both dengue and Zika viruses are prevalent.
Not a fit: Patients who are not pregnant or those who have never been exposed to dengue virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of Zika virus risks in pregnant women, potentially reducing the incidence of birth defects.
How similar studies have performed: Previous research has shown that preexisting immunity to dengue can affect the outcomes of Zika virus infections, indicating that this area of study is both relevant and critical.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Lim, Jean Kyou — Icahn School of Medicine at Mount Sinai
- Study coordinator: Lim, Jean Kyou
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.