Understanding how maternal B cells respond to pregnancy and infections.
Maternal B cells in health and disease.
['FUNDING_R01'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10947627
This study is looking at how a mother’s immune cells, called B cells, respond to different substances during pregnancy, and it aims to understand how these responses can sometimes cause problems for both mom and baby, with the hope of finding ways to create vaccines that keep them healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10947627 on ClinicalTrials.gov |
What this research studies
This research investigates how maternal B cells and their antibody responses interact with placental and foreign antigens during pregnancy. By examining two specific checkpoints that regulate these responses, the study aims to uncover how dysregulated immune responses can lead to complications in pregnancy. The research employs advanced techniques to analyze the interactions between B cells and modified placental antigens, which could inform the development of vaccines to protect mothers and their children from infections. The findings could provide insights into improving maternal and child health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women and mothers who are at risk of pregnancy complications or infections.
Not a fit: Patients who are not pregnant or do not have a history of pregnancy complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better vaccines and treatments that protect mothers and children from infections during pregnancy.
How similar studies have performed: Previous research has shown success in understanding immune responses during pregnancy, but this specific approach focusing on placental antigens is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIZZUTO, GABRIELLE A — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: RIZZUTO, GABRIELLE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.