Understanding how maternal B cells respond to pregnancy and infections.
Official title: Maternal B cells in health and disease.
Funded at Sloan-Kettering Inst Can Research · NIH-10947627 · Data updated 2026-11-12
This study is looking at how a mother’s immune cells, called B cells, respond to different substances during pregnancy, and it aims to understand how these responses can sometimes cause problems for both mom and baby, with the hope of finding ways to create vaccines that keep them healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 6, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $633,074 |
| NIH project number | 1R01AI184571-01 |
| Project ID | NIH-10947627 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant women and mothers who are at risk of pregnancy complications or infections.
✕Less likely to help
Patients who are not pregnant or do not have a history of pregnancy complications may not benefit from this research.
What this research studies
This research investigates how maternal B cells and their antibody responses interact with placental and foreign antigens during pregnancy. By examining two specific checkpoints that regulate these responses, the study aims to uncover how dysregulated immune responses can lead to complications in pregnancy. The research employs advanced techniques to analyze the interactions between B cells and modified placental antigens, which could inform the development of vaccines to protect mothers and their children from infections. The findings could provide insights into improving maternal and child health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better vaccines and treatments that protect mothers and children from infections during pregnancy.
How similar studies have gone: Previous research has shown success in understanding immune responses during pregnancy, but this specific approach focusing on placental antigens is relatively novel.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Rizzuto, Gabrielle a — Sloan-Kettering Inst Can Research
- Study coordinator: Rizzuto, Gabrielle a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.