Understanding how maternal antibodies affect HIV transmission from mother to child
Escape of maternal plasma broadly neutralizing antibody as a mechanism of mother to child HIV transmission
This study is looking at how certain antibodies from mothers might accidentally help pass HIV to their babies, and it aims to find better ways to prevent this from happening, especially for moms and their little ones living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10906665 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which maternal antibodies can inadvertently facilitate the transmission of HIV from mothers to their infants. It focuses on the role of broadly neutralizing antibodies (bnAbs) in maternal plasma and how these antibodies may lead to the development of viral escape variants in infants. By analyzing the interactions between maternal antibodies and the virus, the study aims to identify strategies that could enhance the effectiveness of existing antiretroviral therapies in preventing mother-to-child transmission of HIV. The research employs a combination of clinical data analysis and laboratory techniques to explore these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research include HIV-positive pregnant women and their infants, particularly those at risk of mother-to-child transmission.
Not a fit: Patients who are not pregnant or who are not HIV-positive may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing HIV transmission from mothers to their infants, potentially saving thousands of lives each year.
How similar studies have performed: Previous research has shown that understanding the dynamics of maternal antibodies can lead to significant advancements in preventing HIV transmission, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Permar, Sallie R. — Weill Medical Coll of Cornell Univ
- Study coordinator: Permar, Sallie R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.