Understanding how mast cells interact with nerves in the esophagus
A Novel Mechanism of Mast Cell-Nerve Interactions in the Esophagus
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10475084
This study is looking at how certain immune cells in the esophagus, called mast cells, work with nerve cells to understand their role in causing pain and discomfort in conditions like GERD and esophagitis, and it’s for anyone who wants to learn more about these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10475084 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mast cells in the esophagus, particularly how they interact with nerve cells in both allergic and non-allergic esophageal disorders. The study focuses on a specific receptor, MrgprB2, which is believed to mediate inflammation and contribute to symptoms like pain and discomfort. By examining both mouse models and human tissues, the researchers aim to characterize the behavior of these mast cells and their impact on esophageal health. This could lead to a better understanding of conditions like GERD and esophagitis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with esophageal disorders such as GERD or esophagitis, particularly those experiencing significant symptoms.
Not a fit: Patients with esophageal disorders that are not related to mast cell activation or inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for esophageal disorders, improving quality of life for patients suffering from conditions like GERD.
How similar studies have performed: Similar research has shown promise in understanding mast cell functions in other tissues, suggesting that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YU, SHAOYONG — JOHNS HOPKINS UNIVERSITY
- Study coordinator: YU, SHAOYONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease, Disorder, Esophageal Diseases