Understanding how mast cells grow and function in airway diseases like asthma
Determining drivers of mast cell expansion and function during human airway disease
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10940784
This study is looking at how certain cells in your airways, called mast cells, behave in conditions like asthma and nasal polyps, to better understand what makes them grow and change, which could help improve treatments for people dealing with these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10940784 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mast cells in airway diseases such as asthma and nasal polyposis. It aims to uncover the mechanisms that lead to the expansion and differentiation of mast cell progenitors in the airway tissues. By studying how structural cells in the airway influence mast cell behavior, the research seeks to identify key signals that drive these processes. The findings could provide insights into how mast cells contribute to inflammation and disease progression in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with asthma or nasal polyposis who are experiencing significant respiratory symptoms.
Not a fit: Patients with airway diseases not involving mast cell involvement or those without a diagnosis of asthma or nasal polyposis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target mast cell behavior, potentially improving outcomes for patients with asthma and related airway diseases.
How similar studies have performed: Previous research has shown that targeting mast cell activity can lead to improvements in asthma management, suggesting that this approach may yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DWYER, DANIEL F — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: DWYER, DANIEL F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway Disease