Understanding how mast cells grow and function in airway diseases like asthma
Official title: Determining drivers of mast cell expansion and function during human airway disease
Funded at Brigham and Women's Hospital · NIH-10940784 · Data updated 2026-11-12
This study is looking at how certain cells in your airways, called mast cells, behave in conditions like asthma and nasal polyps, to better understand what makes them grow and change, which could help improve treatments for people dealing with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $715,968 |
| NIH project number | 1R01HL174622-01 |
| Project ID | NIH-10940784 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with asthma or nasal polyposis who are experiencing significant respiratory symptoms.
✕Less likely to help
Patients with airway diseases not involving mast cell involvement or those without a diagnosis of asthma or nasal polyposis may not benefit from this research.
What this research studies
This research investigates the role of mast cells in airway diseases such as asthma and nasal polyposis. It aims to uncover the mechanisms that lead to the expansion and differentiation of mast cell progenitors in the airway tissues. By studying how structural cells in the airway influence mast cell behavior, the research seeks to identify key signals that drive these processes. The findings could provide insights into how mast cells contribute to inflammation and disease progression in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target mast cell behavior, potentially improving outcomes for patients with asthma and related airway diseases.
How similar studies have gone: Previous research has shown that targeting mast cell activity can lead to improvements in asthma management, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Dwyer, Daniel F — Brigham and Women's Hospital
- Study coordinator: Dwyer, Daniel F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.