Understanding how mast cells develop and function in allergic diseases
Official title: Mast Cell Lineage Commitment and Function
Funded at National Jewish Health · NIH-11050939 · Data updated 2026-11-12
This study is looking at how a gene called MITF affects mast cells, which play a big role in allergies, by using specially modified mice to see how this gene influences allergy-related cells; the goal is to better understand why some people have more allergies and to find new ways to help treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | December 2, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $612,328 |
| NIH project number | 1R01AI182277-01A1 |
| Project ID | NIH-11050939 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from allergic diseases or mast cell activation syndrome.
✕Less likely to help
Patients with non-allergic conditions or those not affected by mast cell-related diseases may not benefit from this research.
What this research studies
This research investigates the role of a specific gene, MITF, in the development and function of mast cells, which are crucial in allergic reactions. By studying genetically modified mice, the researchers aim to understand how MITF influences the expression of genes related to mast cells and suppresses those related to basophils. This could lead to insights into why some individuals are more susceptible to allergies and how mast cells contribute to allergic diseases. The findings may help identify new therapeutic targets for treating allergic conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for allergic diseases and conditions related to mast cell activation.
How similar studies have gone: Previous research has shown promising results in understanding mast cell biology and its implications for allergy treatment, indicating that this approach has potential for success.
Where this research is happening
-
National Jewish Health
Denver, United States Active
Researchers
- Principal investigator: Huang, Hua — National Jewish Health
- Study coordinator: Huang, Hua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.