Understanding how mast cells behave in asthma
Origin and Function of Intra-epithelial Mast Cells in Asthma
This study is looking at how certain immune cells called mast cells behave in asthma, especially how they move and interact with other cells in the airways, to better understand what makes asthma symptoms worse and how a protein called IL-33 might be involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10818616 on NIH RePORTER |
What this research studies
This research investigates the role of mast cells in asthma, particularly how they move from the submucosa to the airway epithelium and their impact on airway hyperresponsiveness. By using advanced imaging techniques, the study aims to uncover the molecular interactions between mast cells and airway epithelial cells, focusing on a specific protein called IL-33 that may drive inflammation in asthma. The research involves both laboratory studies and animal models to explore these mechanisms and their relevance to asthma severity in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young adults aged 0-21 who have been diagnosed with asthma.
Not a fit: Patients with asthma who do not have significant airway hyperresponsiveness may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target mast cell behavior and improve asthma management.
How similar studies have performed: Previous research has shown promising results in understanding the role of mast cells in asthma, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Hallstrand, Teal S — University of Washington
- Study coordinator: Hallstrand, Teal S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.