Understanding How Mast Cells Affect Immune Function and Diseases
Transcriptional mechanisms in mast cells underlying immune function and disease
This project explores how certain immune cells called mast cells respond to stress and infection, influencing brain function and conditions like anxiety and depression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11132703 on NIH RePORTER |
What this research studies
Our bodies have special immune cells called mast cells that quickly react to stress and infections, releasing chemicals that can affect our brain and overall health. These cells play a role in conditions like allergies, anxiety, and depression by influencing inflammation and how our brain functions. We are learning more about how genes control these mast cells, especially a newly found factor called ΔFosB, which seems to limit their activity. By understanding these genetic controls, we hope to find new ways to manage the impact of stress and infection on our well-being.
Who could benefit from this research
Good fit: This research is relevant for individuals experiencing conditions such as allergies, anxiety, depression, or other stress- and infection-related illnesses.
Not a fit: Patients without conditions related to mast cell activity, neuroinflammation, or stress-induced psychiatric symptoms may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to target mast cells to treat conditions related to stress, infection, allergies, anxiety, and depression.
How similar studies have performed: This project builds on the researchers' own preliminary findings about a newly discovered genetic factor, suggesting a novel approach to understanding mast cell regulation.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Robison, Alfred J — Michigan State University
- Study coordinator: Robison, Alfred J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.