Understanding how manganese exposure affects brain health through a specific protein
Mechanism of Manganese-induced neurotoxicity via microglial Leucine Rich Repeat Kinase 2 (LRRK2)
['FUNDING_R01'] · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · NIH-11130601
This study is looking at how long-term exposure to manganese might affect brain health and contribute to symptoms like Parkinson's disease, focusing on a specific protein that could help us understand the risks of environmental toxins for people with neurological issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FLORIDA AGRICULTURAL AND MECHANICAL UNIV (nih funded) |
| Locations | 1 site (TALLAHASSEE, UNITED STATES) |
| Trial ID | NIH-11130601 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of chronic manganese exposure on brain health, particularly focusing on a protein called Leucine-rich repeat kinase 2 (LRRK2). The study aims to uncover the mechanisms by which manganese induces neurotoxicity, which can lead to symptoms similar to Parkinson's disease. By examining how manganese influences LRRK2 activity and its role in microglial responses, the research seeks to clarify the relationship between environmental toxins and neurological disorders. Patients may benefit from insights into how to mitigate risks associated with manganese exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic exposure to manganese, particularly those in occupational settings.
Not a fit: Patients who have not been exposed to manganese or do not exhibit neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for manganese-induced neurological diseases.
How similar studies have performed: Previous research has shown that understanding the role of LRRK2 in neurotoxicity can lead to significant advancements in treating related neurological conditions.
Where this research is happening
TALLAHASSEE, UNITED STATES
- FLORIDA AGRICULTURAL AND MECHANICAL UNIV — TALLAHASSEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, EUN SOOK YU — FLORIDA AGRICULTURAL AND MECHANICAL UNIV
- Study coordinator: LEE, EUN SOOK YU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.