Understanding how manganese affects the effectiveness of antibiotics against Staphylococcus aureus
Official title: Identifying the role of manganese limitation in antibiotic killing of Staphylococcus aureus
Funded at Univ of North Carolina Chapel Hill · NIH-10978200 · Data updated 2026-11-12
This study is looking at how manganese affects the power of antibiotics to fight off Staphylococcus aureus, a tough bacteria that can cause infections, to find new ways to make treatments more effective, especially for those dealing with antibiotic-resistant infections.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | December 1, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $47,367 |
| NIH project number | 5F30AI169746-03 |
| Project ID | NIH-10978200 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with Staphylococcus aureus infections, especially those experiencing treatment failures due to antibiotic resistance.
✕Less likely to help
Patients with infections caused by other types of bacteria or those not infected with Staphylococcus aureus may not benefit from this research.
What this research studies
This research investigates the role of manganese in enhancing the effectiveness of antibiotics against Staphylococcus aureus, a common and challenging bacterial pathogen. The study aims to understand how manganese limitation can improve antibiotic efficacy, potentially reducing treatment failures associated with antibiotic-resistant infections. By examining the interaction between manganese levels and antibiotic activity, the research seeks to identify new strategies to combat these difficult infections. The approach includes laboratory experiments that analyze bacterial behavior in low-manganese conditions and its impact on antibiotic susceptibility.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from Staphylococcus aureus infections, particularly those that are resistant to current antibiotics.
How similar studies have gone: Other research has shown promising results in enhancing antibiotic efficacy through manipulation of metal ion availability, suggesting that this approach may be viable.
Where this research is happening
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Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Velez, Amanda Zoyla — Univ of North Carolina Chapel Hill
- Study coordinator: Velez, Amanda Zoyla
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.