Understanding how manganese affects the brain and its excretion
Role and mechanisms of excretion in manganese neurotoxicity
['FUNDING_R01'] · UNIVERSITY OF TEXAS AT AUSTIN · NIH-11103870
This study looks at how high levels of manganese can harm the brain and how our bodies get rid of this metal, especially in people with liver problems or certain genetic traits, to help us understand why some folks might be more at risk for manganese-related brain issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS AT AUSTIN (nih funded) |
| Locations | 1 site (AUSTIN, UNITED STATES) |
| Trial ID | NIH-11103870 on ClinicalTrials.gov |
What this research studies
This research investigates the harmful effects of elevated manganese levels on the brain and how the body excretes this metal. It focuses on understanding the mechanisms of manganese excretion through the liver and intestines, particularly in individuals with liver disease or genetic variations that affect excretion capacity. By studying specific transporters involved in manganese excretion, the research aims to clarify the relationship between manganese levels and neurotoxicity. This could lead to insights into why some individuals are more susceptible to manganese-related neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with elevated manganese levels, particularly those with liver disease or genetic predispositions affecting manganese excretion.
Not a fit: Patients without elevated manganese levels or those not affected by manganese neurotoxicity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for manganese-induced neurotoxicity.
How similar studies have performed: Previous research has shown promising results in understanding metal excretion and its effects on health, suggesting that this approach could yield valuable insights.
Where this research is happening
AUSTIN, UNITED STATES
- UNIVERSITY OF TEXAS AT AUSTIN — AUSTIN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUKHOPADHYAY, SOMSHUVRA — UNIVERSITY OF TEXAS AT AUSTIN
- Study coordinator: MUKHOPADHYAY, SOMSHUVRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.