Understanding how mammalian cells shape themselves during development
Mechanics of mammalian morphogenesis
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-10911884
This study looks at how mammal cells change shape to create different tissues, which could help us understand developmental disorders and improve tissue engineering for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10911884 on ClinicalTrials.gov |
What this research studies
This research investigates the process of morphogenesis, focusing on how mammalian cells change shape to form complex tissues. It explores the mechanisms behind apical constriction, a key cellular shape change that helps position and differentiate cells during development. By studying the proteins involved in this process and their dynamics, the research aims to uncover how these cellular behaviors are regulated in mammals compared to other organisms. Patients may benefit from insights gained into developmental disorders or tissue engineering applications.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic or developmental disorders affecting tissue formation.
Not a fit: Patients with conditions unrelated to developmental processes or tissue architecture may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding developmental disorders and improving tissue engineering techniques.
How similar studies have performed: Other research has shown success in understanding cellular mechanisms in non-mammalian models, but this specific focus on mammalian apical constriction is relatively novel.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUMIGRAY, KAELYN D. — YALE UNIVERSITY
- Study coordinator: SUMIGRAY, KAELYN D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.