Understanding how mammalian cells shape themselves during development
Official title: Mechanics of mammalian morphogenesis
Funded at Yale University · NIH-10911884 · Data updated 2026-11-12
This study looks at how mammal cells change shape to create different tissues, which could help us understand developmental disorders and improve tissue engineering for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $418,750 |
| NIH project number | 5R35GM150645-02 |
| Project ID | NIH-10911884 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with genetic or developmental disorders affecting tissue formation.
✕Less likely to help
Patients with conditions unrelated to developmental processes or tissue architecture may not receive benefit from this research.
What this research studies
This research investigates the process of morphogenesis, focusing on how mammalian cells change shape to form complex tissues. It explores the mechanisms behind apical constriction, a key cellular shape change that helps position and differentiate cells during development. By studying the proteins involved in this process and their dynamics, the research aims to uncover how these cellular behaviors are regulated in mammals compared to other organisms. Patients may benefit from insights gained into developmental disorders or tissue engineering applications.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding developmental disorders and improving tissue engineering techniques.
How similar studies have gone: Other research has shown success in understanding cellular mechanisms in non-mammalian models, but this specific focus on mammalian apical constriction is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Sumigray, Kaelyn D. — Yale University
- Study coordinator: Sumigray, Kaelyn D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.