Understanding how mammalian body clocks work and their effects on health
Mammalian circadian rhythms: from genes to mechanisms
This study is looking at how our body's internal clocks work in mice and how changes in these clocks might affect brain health as we age, with the hope of finding new ways to help prevent or treat conditions like Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11092007 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of circadian rhythms in mammals, focusing on how these biological clocks regulate essential cellular and physiological processes. By using advanced mouse models, the study aims to uncover the roles of specific genes and proteins in maintaining these rhythms and their impact on age-related neurodegenerative conditions. The research combines genetic screening with mechanistic studies to explore how disruptions in circadian rhythms may contribute to neurodegeneration, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related neurodegenerative conditions or those interested in the effects of circadian rhythms on health.
Not a fit: Patients with acute neurodegenerative conditions unrelated to circadian rhythms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for age-related neurodegenerative diseases by targeting circadian rhythm disruptions.
How similar studies have performed: Previous research has shown promising results in understanding circadian rhythms and their implications for health, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Yoo, Seung-Hee — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Yoo, Seung-Hee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.