Understanding how mammal digit tips regenerate after amputation
Composite tissue patterning in mammalian digit tip regeneration
This study is exploring how the tips of fingers and toes can grow back after being cut off, focusing on the special cells that help rebuild them, and it’s for anyone interested in understanding how our bodies can heal and regenerate.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11064772 on NIH RePORTER |
What this research studies
This research investigates the complex process of how digit tips in mammals, including humans, can regenerate after being amputated. It focuses on the role of a structure called the 'blastema', which is formed by various cell types that work together to rebuild the digit tip. The study aims to uncover the molecular mechanisms that guide the organization and shaping of this tissue during regeneration, particularly how signals from the nail epithelium influence this process. By comparing mammalian regeneration to embryonic limb development, the research seeks to identify unique patterns and cues that facilitate successful tissue regeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced digit tip amputations and are interested in regenerative medicine.
Not a fit: Patients with amputations of other body parts or those who do not have the capacity for regeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance or enable limb regeneration in humans.
How similar studies have performed: While there has been success in understanding limb regeneration in non-mammalian models, this research explores novel mechanisms specific to mammalian digit regeneration.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lehoczky, Jessica a — Brigham and Women's Hospital
- Study coordinator: Lehoczky, Jessica a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.