Understanding how male reproductive structures develop under the influence of androgens
Mechanisms of androgen-dependent Wolffian duct differentiation
This study is looking at how certain hormones help shape a part of the male reproductive system in mice, which could help us understand problems with male infertility linked to this development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11085075 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind the differentiation of the Wolffian duct, a crucial structure for male reproductive organ development, which is influenced by androgens. The study utilizes a specialized mouse model to explore how androgen receptors in the mesenchyme affect this process. By analyzing gene expression and chromatin accessibility, the research aims to identify key factors that regulate Wolffian duct development. This could provide insights into male infertility issues related to abnormal Wolffian duct formation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include males experiencing infertility issues related to developmental abnormalities.
Not a fit: Patients with infertility not linked to Wolffian duct development or those with other unrelated reproductive health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for male infertility caused by developmental defects in reproductive structures.
How similar studies have performed: Previous research has shown promising results in understanding androgen signaling in reproductive development, suggesting that this approach could yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Zhao, Fei — University of Wisconsin-Madison
- Study coordinator: Zhao, Fei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.