Understanding how male and female external genitalia develop
Diversification of cell types during male and female external genital development
This study looks at how male and female genitalia develop differently in mice and how certain chemicals in the environment might affect this process, especially in boys with conditions like hypospadias, to help find ways to prevent these issues in the future.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10932494 on NIH RePORTER |
What this research studies
This research investigates the cellular differences in the development of male and female external genitalia using mouse models. It focuses on congenital malformations such as hypospadias, which affects a significant number of male births. By examining how environmental factors, particularly endocrine disrupting chemicals, influence genital development at the single cell level, the study aims to uncover the mechanisms behind these conditions. The findings could lead to new prevention strategies for congenital abnormalities.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include families with a history of congenital malformations of the external genitalia, particularly hypospadias.
Not a fit: Patients with congenital malformations unrelated to external genitalia development may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights that help prevent congenital malformations of the external genitalia in newborns.
How similar studies have performed: Other research has shown success in understanding congenital malformations through similar cellular and environmental investigations, indicating a promising approach.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Cohn, Martin J — University of Florida
- Study coordinator: Cohn, Martin J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.