Understanding how male and female external genitalia develop
Diversification of cell types during male and female external genital development
This study looks at how male and female genitalia develop differently in mice and explores how certain chemicals in the environment might cause issues like hypospadias, a condition that affects many baby boys, with the hope of finding ways to prevent these problems in the future.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10899472 on NIH RePORTER |
What this research studies
This research investigates the cellular differences in the development of male and female external genitalia using mouse models. It focuses on congenital malformations, particularly hypospadias, which affects a significant number of male births. By examining how environmental factors, such as endocrine disrupting chemicals, influence genital development at the single cell level, the research aims to uncover the mechanisms behind these conditions. This could lead to new prevention strategies for congenital abnormalities.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborn males diagnosed with congenital malformations of the external genitalia, such as hypospadias.
Not a fit: Patients with congenital malformations unrelated to external genitalia development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to better prevention and treatment options for congenital malformations of the external genitalia.
How similar studies have performed: Previous research has shown success in understanding congenital malformations through similar cellular and environmental investigations, although this specific approach is relatively novel.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Cohn, Martin J — University of Florida
- Study coordinator: Cohn, Martin J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.