Understanding how malaria persists in Africa despite treatment advances
Relapsing malaria in Africa: mechanisms for persistence amid falciparum decline
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11135641
This study is looking into how certain types of malaria, specifically Plasmodium ovale and Plasmodium vivax, continue to affect people in Africa even as other types are becoming less common, and it aims to find better ways to control these infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11135641 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the persistence of malaria caused by Plasmodium ovale and Plasmodium vivax in Africa, particularly as Plasmodium falciparum infections decline. The study employs advanced molecular diagnostics and high-throughput genotyping to explore the transmission biology and relapse patterns of these malaria species. By focusing on the unique challenges posed by dormant liver stages and early transmissible life cycle stages, the research aims to provide insights that could improve malaria control strategies in affected regions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living in malaria-endemic regions of Africa, particularly those experiencing recurrent malaria infections.
Not a fit: Patients who do not reside in malaria-endemic areas or those who have never been infected with malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective malaria treatment and prevention strategies, ultimately reducing the burden of malaria in Africa.
How similar studies have performed: While there has been limited research on Plasmodium ovale and Plasmodium vivax in Africa, similar studies in other regions have shown promise in understanding malaria transmission and relapse mechanisms.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JULIANO, JONATHAN J — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: JULIANO, JONATHAN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.