Understanding how malaria parasites use a specific nutrient for survival
Cofactor metabolism and mitochondrial function in malaria parasites
This study is looking at how malaria parasites get and use a nutrient called lipoate while they grow in red blood cells, which could help us find new ways to treat malaria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10910015 on NIH RePORTER |
What this research studies
This research investigates how malaria parasites, specifically Plasmodium falciparum, utilize a vital nutrient called lipoate during their development in red blood cells. The study focuses on the mechanisms by which these parasites acquire lipoate from their human hosts and how it is used in their mitochondria. By employing biochemical, cell biology, and genetic techniques, the researchers aim to uncover the essential roles of lipoate-dependent proteins and the processes involved in lipoate uptake. This knowledge could lead to new strategies for targeting the parasites and improving treatment options for malaria.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in malaria-endemic regions who may be at risk of malaria infection.
Not a fit: Patients who do not reside in malaria-endemic areas or those who have already been treated for malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for malaria by targeting the nutrient acquisition mechanisms of the parasites.
How similar studies have performed: Other research has shown success in targeting nutrient acquisition in parasites, indicating that this approach may yield promising results.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Prigge, Sean Taylor — Johns Hopkins University
- Study coordinator: Prigge, Sean Taylor
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.