Understanding how malaria parasites resist treatment with certain drugs
Leveraging PfCRT Structure to Discern Function and Predict Emergence of Drug-Resistant Malaria
This study is looking at how certain genes in the malaria parasite might help it resist treatment, so we can find better ways to fight malaria and help patients get the care they need.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11058808 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to drug resistance in the malaria parasite Plasmodium falciparum. By studying the structure of a specific protein involved in drug transport, the team aims to understand how variations in this protein affect the parasite's ability to resist treatment. The research employs advanced techniques such as cryo-electron microscopy, functional assays, and computational modeling to explore these mechanisms. Patients may benefit from insights that could lead to more effective malaria treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with malaria, particularly those infected with drug-resistant strains of Plasmodium falciparum.
Not a fit: Patients with malaria caused by other species of the parasite or those who are not infected with malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new strategies to combat drug-resistant malaria, improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown success in understanding drug resistance mechanisms in malaria, indicating that this approach has the potential for significant findings.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Mancia, Filippo — Columbia University Health Sciences
- Study coordinator: Mancia, Filippo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.