Understanding how malaria parasites multiply in mosquitoes
Development and Composition of the Basal Complex During Plasmodium Sporogony
['FUNDING_R21'] · PENNSYLVANIA STATE UNIVERSITY, THE · NIH-11094083
This study is looking at how malaria parasites grow inside mosquitoes and how they turn into the infectious form that can spread the disease, with the goal of finding ways to stop malaria from being transmitted.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIVERSITY, THE (nih funded) |
| Locations | 1 site (UNIVERSITY PARK, UNITED STATES) |
| Trial ID | NIH-11094083 on ClinicalTrials.gov |
What this research studies
This research investigates the complex process by which malaria parasites, specifically Plasmodium, multiply within mosquitoes. It focuses on the formation of sporozoites, which are the infectious stage of the parasite, and how they are produced from the initial parasite through a process called segmentation. Using advanced imaging techniques like 3D microscopy and proximity proteomics, the study aims to uncover the composition and function of the basal complex that directs this segmentation. By understanding these mechanisms, the research hopes to provide insights into malaria transmission and potential interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in malaria-endemic regions, particularly those who may be at risk of malaria infection.
Not a fit: Patients who do not reside in malaria-endemic areas or those who are not at risk of malaria infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for controlling malaria transmission by targeting the lifecycle of the parasite in mosquitoes.
How similar studies have performed: Previous research has shown success in understanding malaria parasite biology, but this specific approach to studying the basal complex during sporozoite formation is novel.
Where this research is happening
UNIVERSITY PARK, UNITED STATES
- PENNSYLVANIA STATE UNIVERSITY, THE — UNIVERSITY PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LINDNER, SCOTT E — PENNSYLVANIA STATE UNIVERSITY, THE
- Study coordinator: LINDNER, SCOTT E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.