Understanding how malaria parasites export proteins to survive in human blood cells
Molecular basis of effector protein export in the malaria parasite Plasmodium falciparum
This study is looking at how the malaria parasite gets proteins into our red blood cells, with the hope of finding new ways to create better treatments for malaria that could help patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10918184 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the malaria parasite Plasmodium falciparum exports proteins into human red blood cells. By studying the complex processes involved in protein export, including how these proteins are transported across membranes, the research aims to identify potential new targets for anti-malarial drugs. The approach involves biochemical assays and advanced molecular techniques to unravel the intricacies of the parasite's interaction with host cells. Patients may benefit from the development of new treatments that could arise from this understanding.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals living in malaria-endemic regions or those at high risk of malaria infection.
Not a fit: Patients who are not at risk of malaria or who live in non-endemic regions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new anti-malarial drugs that are effective against drug-resistant strains of the parasite.
How similar studies have performed: Other research has shown promise in targeting similar pathways in intracellular pathogens, indicating that this approach could lead to significant advancements in malaria treatment.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Ho, Chi-Min — Columbia University Health Sciences
- Study coordinator: Ho, Chi-Min
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.